Syngeneic Models

What is syngeneic mouse model​?

A syngeneic mouse model is an experimental tool used in biomedical research, particularly in the study of cancer and immunology. In this model, tumor cells derived from a mouse of a specific inbred strain are implanted into a genetically identical mouse of the same strain. This genetic compatibility allows the host mouse's immune system to recognize the tumor cells as "self," thus preventing an immune rejection of the graft.

Syngeneic mouse models are valuable for studying tumor biology and evaluating the efficacy of cancer therapies, including immunotherapies, as they provide a more realistic tumor microenvironment compared to other models. These models help researchers investigate the tumor-immune system interactions, drug responses, and mechanisms underlying cancer progression and metastasis. By using syngeneic mouse models, scientists can gain crucial insights into potential therapeutic targets and treatment strategies.